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Structure of 1360914-08-4
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2-cyclobutyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a bench-stable boronate reagent featuring a cyclobutyl substituent that enhances steric and electronic control in cross-coupling reactions. The tetramethyl substitution stabilizes the dioxaborolane ring against hydrolysis while maintaining reactivity under standard Suzuki-Miyaura conditions. This compound integrates efficiently into complex molecular architectures with minimal side reactivity.
2-Cyclobutyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boron building block for Suzuki-Miyaura cross-coupling reactions. Its sterically protected boronate ester enables reliable coupling with aryl and vinyl halides under mild conditions, offering excellent functional group tolerance and ease of purification. The cyclobutyl substituent provides a rigid, lipophilic moiety useful in medicinal chemistry scaffolds, enhancing metabolic stability while maintaining reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319-H335
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Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: