5-Bromo-4-ethylpyridin-2-amine

Name: 5-Bromo-4-ethylpyridin-2-amine
Brand: ChemScene
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CAS No. 1368352-40-2
Cat. No. CS-0334320
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-4-ethylpyridin-2-amine|CS-0334320

Structure of 1368352-40-2

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Description

5-Bromo-4-ethylpyridin-2-amine features a bromine substituent at the 5-position and an ethyl group at the 4-position on a pyridine ring bearing a primary amine at the 2-position. This electron-deficient heterocycle integrates readily into cross-coupling reactions, enabling efficient access to functionalized pyridine scaffolds under standard conditions.

Application

5-Bromo-4-ethylpyridin-2-amine serves as a versatile building block in medicinal chemistry and catalytic synthesis. Its pyridine core enables transition-metal-catalyzed cross-coupling reactions, while the bromo and amine groups offer orthogonal reactivity for sequential functionalization. The ethyl substituent enhances solubility and modulates electronic properties, contributing to favorable handling and purification. This compound functions effectively in Suzuki-Miyaura, Buchwald-Hartwig, and related transformations, facilitating access to complex heterocyclic scaffolds common in pharmaceutical development.

General Information

CAS No. 1368352-40-2
Cat. No. CS-0334320
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₉BrN₂
Molecular Weight 201.06
Synonym(s) 5-Bromo-4-ethyl-pyridin-2-ylamine
SMILES NC1=NC=C(Br)C(CC)=C1

Computational Chemistry Data

TPSA 38.91
LogP 1.9887
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromo-4-ethylpyridin-2-amine

CAS No. 1368352-40-2

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