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(1S)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride

  • CAS No. 1391354-92-9

  • Cat. No. CS-0021529
  • Molecule weight187.64
  • Purity≥98%
  • MDL No.MFCD16295142

*For research and further manufacturing use only, not for direct human use.

(1S)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride|CS-0021529

Structure of 1391354-92-9

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General Information

  • CAS No. 1391354-92-9
  • Cat. No. CS-0021529
  • Purity ≥98%
  • MDL No. MFCD16295142
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁ClFN
  • Molecular Weight 187.64
  • Synonym(s) =-6-Fluoroindan-1-amine hydrochloride
  • SMILES N[C@H]1CCC2=C1C=C(F)C=C2.Cl

Description

This chiral amine features a fluorinated indene core with a bench-stable hydrochloride salt, enabling straightforward handling and integration into asymmetric synthesis. The (1S) stereochemistry ensures high enantioselectivity in catalytic transformations, particularly in transition-metal-catalyzed C–H functionalizations and organocatalytic reactions.

Application

(1S)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride serves as a chiral building block for asymmetric synthesis, offering high stereochemical integrity and bench stability. The fluorinated indene scaffold provides enhanced metabolic resistance and modulated lipophilicity, enabling its use in medicinal chemistry campaigns targeting CNS and oncology therapeutics. It functions effectively in amine coupling reactions, metal-catalyzed cross-couplings, and reductive amination protocols, with the hydrochloride salt ensuring ease of handling and purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.1935
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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