(1S,2R)-2-Fluorocyclopropan-1-amine hydrochloride

Name: (1S,2R)-2-Fluorocyclopropan-1-amine hydrochloride
Brand: ChemScene
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CAS No. 141042-20-8
Cat. No. CS-0143340
Purity≥97%
MDL No.MFCD19207082

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(1S,2R)-2-Fluorocyclopropan-1-amine hydrochloride|CS-0143340

Structure of 141042-20-8

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Description

This fluorinated cyclopropanamine derivative features a strained three-membered ring system with stereochemically defined (1S,2R) configuration. The pendant amine group, delivered as the hydrochloride salt, enhances solubility and stability under standard conditions. This scaffold serves as a key building block in medicinal chemistry, particularly for probing conformationally restricted bioactive molecules.

Application

(1S,2R)-2-Fluorocyclopropan-1-amine hydrochloride serves as a conformationally constrained building block for medicinal chemistry, enabling the introduction of stereo-defined fluorinated cyclopropyl motifs into bioactive molecules. The compound exhibits excellent bench stability, facilitates direct incorporation into peptide and heterocyclic scaffolds, and demonstrates broad compatibility with standard amine functionalization protocols. Its defined stereochemistry supports reproducible synthetic outcomes in target-oriented synthesis.

General Information

CAS No. 141042-20-8
Cat. No. CS-0143340
Purity ≥97%
MDL No. MFCD19207082
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₇ClFN
Molecular Weight 111.55
Synonym(s) None
SMILES N[C@@H]1[C@H](F)C1.Cl

Computational Chemistry Data

TPSA 26.02
LogP 0.4773
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(1S,2R)-2-Fluorocyclopropan-1-amine hydrochloride

CAS No. 141042-20-8

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