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Structure of 1416372-95-6
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This bench-stable arylmethanol features a para-amino group flanked by a trifluoromethyl substituent, delivering enhanced electron density and solubility in polar organic solvents. The functional handle enables direct coupling in amide formation or reductive amination workflows, streamlining access to complex pharmaceutical intermediates.
(4-Amino-3-(trifluoromethyl)phenyl)methanol serves as a versatile building block in medicinal chemistry, enabling the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its amino and hydroxymethyl groups offer orthogonal reactivity for coupling, derivatization, and protection strategies. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the molecule exhibits good bench stability and facilitates straightforward purification—ideal for iterative synthetic workflows in API development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: