6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride

Name: 6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1420294-83-2
Cat. No. CS-0133674
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride|CS-0133674

Structure of 1420294-83-2

Size

Price

Quantity

* Please select Quantity before adding items.

Description

6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride is a rigid, electron-deficient spirocyclic amine featuring two fluorine atoms at the 6-position, enhancing metabolic stability and modulating lipophilicity. This bench-stable salt form improves solubility and handling in synthetic workflows, enabling efficient incorporation into bioactive molecules.

Application

6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride serves as a conformationally constrained, fluorinated heterocyclic building block for medicinal chemistry applications. Its spirocyclic scaffold imparts rigidity and metabolic stability, while the difluoro substitution enhances membrane permeability and modulates pKa. The hydrochloride salt ensures excellent solubility and bench stability, enabling straightforward handling in standard coupling and functionalization reactions. Functions effectively in the synthesis of bioactive molecules requiring defined stereochemistry and enhanced pharmacokinetic properties.

General Information

CAS No. 1420294-83-2
Cat. No. CS-0133674
Purity ≥98%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₀ClF₂N
Molecular Weight 169.60
Synonym(s) None
SMILES FC(C1)(F)CC21CNC2.[H]Cl

Computational Chemistry Data

TPSA 12.03
LogP 1.4269
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

1420294-83-2 sigma1420294-83-2 manufacturer1420294-83-2 price1420294-83-2 structure1420294-83-2 SDSbuy 1420294-83-21420294-83-2 supplier1420294-83-2 uses1420294-83-2 molecular weightprice of 1420294-83-21420294-83-2 chemical name formula of 1420294-83-2

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

6,6-Difluoro-2-azaspiro[3.3]heptane hydrochloride

CAS No. 1420294-83-2

Recommended Products