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CS-W001157 4
Total: USD 88.00

Benzenemethanamine, 4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]-

  • CAS No. 1426520-69-5

  • Cat. No. CS-0162294
  • Purity≥98%
  • MDL No.MFCD29033786
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Benzenemethanamine, 4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]-|CS-0162294

Structure of 1426520-69-5

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Description

4-[4-[4-(Trifluoromethoxy)phenyl]-1-piperidinyl]benzenemethanamine is a structurally defined tertiary amine featuring a trifluoromethoxy-substituted aryl piperidine motif. This electron-rich scaffold integrates a flexible piperidine ring with a benzylamine handle, enabling targeted conjugation and molecular diversification in medicinal chemistry applications. The trifluoromethoxy group enhances lipophilicity and metabolic stability, while the overall architecture supports high-affinity binding in receptor-targeted drug discovery.

Application

4-[4-[4-(Trifluoromethoxy)phenyl]-1-piperidinyl]benzenemethanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its piperidine core offers favorable solubility and metabolic stability, while the trifluoromethoxy group enhances lipophilicity and target binding affinity. The primary amine functions as a handle for conjugation or salt formation, facilitating purification and formulation. This compound demonstrates robust bench stability and compatibility with standard coupling reactions, making it well-suited for iterative synthesis workflows in API development.

General Information

  • CAS No. 1426520-69-5
  • Cat. No. CS-0162294
  • Purity ≥98%
  • MDL No. MFCD29033786
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₂₁F₃N₂O
  • Molecular Weight 350.38
  • Synonym(s) None
  • SMILES NCC1=CC=C(N2CCC(C3=CC=C(OC(F)(F)F)C=C3)CC2)C=C1

Computational Chemistry Data

  • TPSA   38.49
  • LogP   4.4279
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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