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Structure of 143306-64-3
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tert-Butyl 8-oxo-5-azaspiro[2.5]octane-5-carboxylate is a sterically shielded spirocyclic scaffold featuring a ketone at C8 and a lactam nitrogen at position 5. This configuration enables direct incorporation into complex heterocycles, delivering structural rigidity and enhanced metabolic stability in medicinal chemistry applications.
tert-Butyl 8-oxo-5-azaspiro[2.5]octane-5-carboxylate serves as a versatile spirocyclic building block for medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles via standard functional group manipulations. The ketone and ester functionalities tolerate diverse reaction conditions, supporting reductive amination, nucleophilic addition, and transition-metal-catalyzed coupling. Bench-stable and readily purified by chromatography, it functions effectively in multistep syntheses of complex scaffolds relevant to drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: