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CS-W001157 4
Total: USD 88.00

3-(Difluoromethyl)-1H-pyrazol-4-amine

  • CAS No. 1443288-79-6

  • Cat. No. CS-0529652
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethyl)-1H-pyrazol-4-amine|CS-0529652

Structure of 1443288-79-6

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General Information

  • CAS No. 1443288-79-6
  • Cat. No. CS-0529652
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅F₂N₃
  • Molecular Weight 133.10
  • Synonym(s) 5-(difluoromethyl)-1H-pyrazol-4-aminehydrochloride
  • SMILES NC1=CNN=C1C(F)F

Description

3-(Difluoromethyl)-1H-pyrazol-4-amine features a difluoromethyl group at the 3-position, enhancing metabolic stability and lipophilicity. The pyrazole core provides a rigid, electron-rich scaffold ideal for hydrogen bonding. This compound integrates readily into bioactive molecules, particularly in kinase inhibitors and agrochemicals, due to its balanced polarity and robustness under standard conditions.

Application

3-(Difluoromethyl)-1H-pyrazol-4-amine serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group adjacent to a hydrogen-bond-donating amine. Its reactivity facilitates direct coupling and functionalization in standard synthetic workflows, with good bench stability and compatibility across diverse reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   0.9295
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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