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(3-Methylcyclobutyl)methanamine hydrochloride

  • CAS No. 1445951-46-1

  • Cat. No. CS-0036376
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Methylcyclobutyl)methanamine hydrochloride|CS-0036376

Structure of 1445951-46-1

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General Information

  • CAS No. 1445951-46-1
  • Cat. No. CS-0036376
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClN
  • Molecular Weight 135.64
  • Synonym(s) C-(3-METHYL-CYCLOBUTYL)-METHYLAMINE HYDROCHLRIDE
  • SMILES CC1CC(CN)C1.Cl

Description

(3-Methylcyclobutyl)methanamine hydrochloride is a bench-stable, moisture-tolerant amine featuring a strained cyclobutyl ring with a methyl substituent. This configuration imparts enhanced nucleophilicity and steric definition, enabling efficient incorporation into bioactive scaffolds. The hydrochloride salt form ensures improved solubility and handling in synthetic workflows.

Application

(3-Methylcyclobutyl)methanamine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard amine functionalization. Its cyclobutyl core imparts conformational rigidity beneficial for target engagement, while the primary amine functionality facilitates straightforward derivatization via alkylation, acylation, and coupling reactions. The hydrochloride salt enhances solubility and stability, supporting reliable handling and purification in synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.413
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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