(S)-1-(2-Aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

Name: (S)-1-(2-Aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1448440-51-4
Cat. No. CS-0435121
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(S)-1-(2-Aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride|CS-0435121

Structure of 1448440-51-4

Size

Price

Quantity

* Please select Quantity before adding items.

Description

This chiral pyrrolidine derivative features a bench-stable, moisture-tolerant structure with a strategically positioned nitrile group and difluorinated ring system. It integrates seamlessly into peptide-based inhibitor scaffolds and enables direct access to constrained bioactive motifs in medicinal chemistry campaigns.

Application

(S)-1-(2-Aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride serves as a versatile chiral building block for medicinal chemistry, enabling access to fluorinated pyrrolidine scaffolds prevalent in bioactive molecules. The difluoro substitution enhances metabolic stability and modulates electronic properties, while the aminoacetyl and carbonitrile groups offer orthogonal handles for further functionalization. Bench-stable and readily purified, it facilitates efficient synthesis of peptidomimetics and kinase inhibitor candidates through standard coupling and cyclization protocols.

General Information

CAS No. 1448440-51-4
Cat. No. CS-0435121
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀ClF₂N₃O
Molecular Weight 225.62
Synonym(s) (S)-1-(2-aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrilehydrochloride
SMILES NCC(N1[C@@H](CC(F)(C1)F)C#N)=O.Cl

Computational Chemistry Data

TPSA 70.12
LogP 0.12668
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

1448440-51-4 sigma1448440-51-4 manufacturer1448440-51-4 price1448440-51-4 structure1448440-51-4 SDSbuy 1448440-51-41448440-51-4 supplier1448440-51-4 uses1448440-51-4 molecular weightprice of 1448440-51-41448440-51-4 chemical name formula of 1448440-51-4

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

(S)-1-(2-Aminoacetyl)-4,4-difluoropyrrolidine-2-carbonitrile hydrochloride

CAS No. 1448440-51-4

Recommended Products