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CS-W001157 4
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5-Chloro[1,2,4]triazolo[1,5-a]pyrazin-2-amine

  • CAS No. 1454653-85-0

  • Cat. No. CS-0039513
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro[1,2,4]triazolo[1,5-a]pyrazin-2-amine|CS-0039513

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General Information

  • CAS No. 1454653-85-0
  • Cat. No. CS-0039513
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClN₅
  • Molecular Weight 169.57
  • Synonym(s) 5-chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine
  • SMILES NC1=NN2C(C=NC=C2Cl)=N1

Description

5-Chloro[1,2,4]triazolo[1,5-a]pyrazin-2-amine delivers a rigid, electron-deficient heterocyclic scaffold ideal for medicinal chemistry applications. This nitrogen-rich core integrates readily into bioactive molecules, offering enhanced metabolic stability and favorable binding interactions in target-directed synthesis.

Application

5-Chloro[1,2,4]triazolo[1,5-a]pyrazin-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of triazolopyrazine scaffolds prevalent in kinase inhibitors and antiviral agents. Its chloro group facilitates nucleophilic substitution reactions, while the pyrazine nitrogen atoms support metal coordination and hydrogen bonding. The compound exhibits good bench stability and is compatible with standard synthetic workflows, simplifying purification and scale-up.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   69.1
  • LogP   0.3599
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   0

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