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CS-W001157 4
Total: USD 88.00

4-(Aminoethyl)-1-N-Boc-piperidine

  • CAS No. 146093-46-1

  • Cat. No. CS-W019744
  • Purity≥97%
  • MDL No.MFCD04038459

*For research and further manufacturing use only, not for direct human use.

4-(Aminoethyl)-1-N-Boc-piperidine|CS-W019744

Structure of 146093-46-1

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General Information

  • CAS No. 146093-46-1
  • Cat. No. CS-W019744
  • Purity ≥97%
  • MDL No. MFCD04038459
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₄N₂O₂
  • Molecular Weight 228.34
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(CCN)CC1

Application

4-(Aminoethyl)-1-N-Boc-piperidine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to piperidine-containing scaffolds. The Boc-protected amine offers stability and orthogonal reactivity, while the primary amine facilitates conjugation or further functionalization. It functions effectively in amide couplings, reductive aminations, and as a precursor in the synthesis of bioactive heterocycles, with excellent bench stability and straightforward purification.

Synthesis

  • Route1
    • null|null
      146093-45-0
    • ~97%
    • In-stock
      4-(Aminoethyl)-1-N-Boc-piperidine|CS-W019744
      146093-46-1

    References

    • Askew, Benny C.; Bednar, Rodney A.; Bednar, Bohumil; Claremon, David A.; Cook, Jacquelynn J.; McIntyre, Charles J.; Hunt, Cecila A.; Gould, Robert J.; Lynch, Robert J.; Lynch Jr., Joseph J.; Gaul, Stanley L.; Stranieri, Maria T.; Sitko, Gary R.; Holahan, Marie A.; Glass, Joan D.; Hamill, Terrence; Gorham, Lynn M.; Prueksaritanont, Thomayant; Baldwin, John J.; Hartman, George D. Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1779 - 1788
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 13 p. 2167 - 2172
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 40, # 12 p. 1779 - 1788

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.9823
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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