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Structure of 1480-87-1
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2-Fluoro-3-nitropyridine features a fluorine atom at the 2-position and a nitro group at the 3-position on the pyridine ring, creating a highly electron-deficient heterocyclic scaffold. This combination enables selective electrophilic substitution and facilitates coupling reactions in medicinal chemistry. The molecule exhibits enhanced reactivity for C–H functionalization and serves as a key intermediate in synthesizing bioactive compounds.
2-Fluoro-3-nitropyridine serves as a versatile building block for the synthesis of functionalized pyridine derivatives, enabling electrophilic substitution and transition-metal-catalyzed coupling reactions. The ortho-fluoro and meta-nitro groups provide complementary reactivity for sequential functionalization, with the nitro group readily reducible to an amine or serving as a directing group in metal-catalyzed transformations. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and agrochemical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: