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CS-W001157 4
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Tert-butyl 4-hydroxybenzylcarbamate

  • CAS No. 149505-94-2

  • Cat. No. CS-0068163
  • Purity≥97%
  • MDL No.MFCD18206146
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Tert-butyl 4-hydroxybenzylcarbamate|CS-0068163

Structure of 149505-94-2

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Description

Tert-butyl 4-hydroxybenzylcarbamate features a phenolic hydroxyl group flanked by a tert-butyl carbamate protecting group, enabling selective deprotection under mild acidic conditions. This combination imparts stability during synthetic manipulations while facilitating precise functionalization in peptide and small-molecule synthesis workflows.

Application

Tert-butyl 4-hydroxybenzylcarbamate serves as a versatile protecting group for primary amines, enabling selective functionalization in complex molecule synthesis. The tert-butyl carbamate moiety offers excellent stability under basic and mildly acidic conditions, while the phenolic hydroxyl group permits orthogonal modifications. It facilitates efficient coupling reactions and is readily cleaved under mild acidic conditions, making it ideal for iterative synthetic sequences in medicinal chemistry and API development.

General Information

  • CAS No. 149505-94-2
  • Cat. No. CS-0068163
  • Purity ≥97%
  • MDL No. MFCD18206146
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO₃
  • Molecular Weight 223.27
  • Synonym(s) tert-butyl N-[(4-hydroxyphenyl)methyl]carbonate
  • SMILES O=C(OC(C)(C)C)NCC1=CC=C(O)C=C1

Computational Chemistry Data

  • TPSA   58.56
  • LogP   2.4169
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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