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CS-W001157 4
Total: USD 88.00

1-(4-Bromo-3,5-difluorophenyl)ethanone

  • CAS No. 1528607-78-4

  • Cat. No. CS-0187926
  • Purity≥96%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(4-Bromo-3,5-difluorophenyl)ethanone|CS-0187926

Structure of 1528607-78-4

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Description

This brominated aryl ketone features a sterically accessible carbonyl group flanked by electron-withdrawing fluorine atoms, enabling efficient coupling in cross-coupling reactions. The para-bromo substituent serves as a reactive handle for palladium-catalyzed transformations, while the difluorophenyl core enhances metabolic stability and lipophilicity in medicinal chemistry applications.

Application

1-(4-Bromo-3,5-difluorophenyl)ethanone serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of complex aryl ketones. Its bromine and difluoro substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and enhanced metabolic stability in bioactive scaffolds. The compound exhibits excellent bench stability, facilitates straightforward purification via recrystallization, and functions reliably in standard coupling and functionalization protocols.

General Information

  • CAS No. 1528607-78-4
  • Cat. No. CS-0187926
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrF₂O
  • Molecular Weight 235.03
  • Synonym(s) None
  • SMILES CC(=O)C1=CC(=C(C(=C1)F)Br)F

Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.9299
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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