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CS-W001157 4
Total: USD 88.00

4,6-Dichloro-5-fluoropyridine-3-carboxylic acid

  • CAS No. 154012-18-7

  • Cat. No. CS-0051097
  • Purity≥96%
  • MDL No.MFCD18256593

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloro-5-fluoropyridine-3-carboxylic acid|CS-0051097

Structure of 154012-18-7

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General Information

  • CAS No. 154012-18-7
  • Cat. No. CS-0051097
  • Purity ≥96%
  • MDL No. MFCD18256593
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₂FNO₂
  • Molecular Weight 209.99
  • Synonym(s) E4,6-Dichloro-5-fluoronicotinic acid
  • SMILES OC(=O)C1=C(Cl)C(F)=C(Cl)N=C1

Description

4,6-Dichloro-5-fluoropyridine-3-carboxylic acid features a highly electron-deficient pyridine core functionalized with chlorine and fluorine substituents at strategic positions, enabling robust coupling reactions. This carboxylic acid derivative serves as a key building block in medicinal chemistry, particularly for constructing bioactive heterocycles via amide or ester formation under standard conditions.

Application

4,6-Dichloro-5-fluoropyridine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated pyridine scaffolds. Its orthogonal reactivity allows selective functionalization at the carboxylic acid and halogen sites, facilitating coupling reactions and heterocycle elaboration. The compound exhibits good bench stability and facilitates purification via standard crystallization or chromatographic methods, supporting scalable synthesis workflows.

Synthesis

  • Route1

    References

    • Sanchez; Gogliotti Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 855 - 859
  • Route2
    • Ethyl 4-hydroxy-5-nitro-6-oxo-1,6-dihydropyridine-3-carboxylate|CS-0159287
      6317-97-1
    • ~%
    • In-stock
      4,6-Dichloro-5-fluoropyridine-3-carboxylic acid|CS-0051097
      154012-18-7

    References

    • Sanchez; Gogliotti Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 855 - 859
  • Route3

    References

    • Sanchez; Gogliotti Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 855 - 859

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.2257
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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