Serpin B9-IN-1

Name: Serpin B9-IN-1
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 154235-77-5
Cat. No. CS-D0343
Purity≥95%
MDL No.MFCD09954949

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 154235-77-5

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General Information

CAS No. 154235-77-5
Cat. No. CS-D0343
Purity ≥95%
MDL No. MFCD09954949
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅NO₃
Molecular Weight None
Synonym(s) BTCA
SMILES O=C(C1=CC=C2N=COC2=C1)O

Description

Serpin B9-IN-1 is a potent, selective inhibitor of the serine protease Serpin B9, designed to interrogate apoptotic pathways and immune regulation. This compound features a stabilized peptidomimetic scaffold with enhanced cellular permeability and metabolic resilience. It enables precise functional studies in inflammatory and autoimmune disease models.

Application

Serpin B9-IN-1 serves as a selective inhibitor of serine protease inhibitor B9, enabling targeted modulation of inflammatory and immune regulatory pathways. This compound functions as a validated tool for probing serpin-mediated proteolytic control in cellular models, offering high specificity and stability under physiological conditions. Its well-defined reactivity profile supports consistent performance in biochemical assays and facilitates downstream mechanistic studies in inflammation research.

Synthesis

Route1
- In-stock
  
  2374-03-0
- ~87%
- In-stock
  
  154235-77-5
References
- Walker, Daniel Patrick; Wishka, Donn G.; Corbett, Jeffrey W.; Rauckhorst, Mark R.; Piotrowski, David W.; Groppi JR., Vincent E. Patent: US2003/73707 A1, 2003 ;
Route2
- In-stock
  
  2374-03-0
- 149-73-5
- ~89%
- In-stock
  
  154235-77-5
References
- Walker, Daniel P.; Wishka, Donn G.; Piotrowski, David W.; Jia, Shaojuan; Reitz, Steven C.; Yates, Karen M.; Myers, Jason K.; Vetman, Tatiana N.; Margolis, Brandon J.; Jacobsen, E. Jon; Acker, Brad A.; Groppi, Vincent E.; Wolfe, Mark L.; Thornburgh, Bruce A.; Tinholt, Paula M.; Cortes-Burgos, Luz A.; Walters, Rodney R.; Hester, Matthew R.; Seest, Eric P.; Dolak, Lester A.; Han, Fusen; Olson, Barbara A.; Fitzgerald, Laura; Staton, Brian A.; Raub, Thomas J.; Hajos, Mihaly; Hoffmann, William E.; Li, Kai S.; Higdon, Nicole R.; Wall, Theron M.; Hurst, Raymond S.; Wong, Erik H.F.; Rogers, Bruce N. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8219 - 8248

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 63.33
LogP 1.526
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Benzooxazole compounds

Key Words

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Serpin B9-IN-1

CAS No. 154235-77-5

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