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CS-W001157 4
Total: USD 88.00

5-Bromo-4,6-dihydroxypyrimidine

  • CAS No. 15726-38-2

  • Cat. No. CS-W002229
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-4,6-dihydroxypyrimidine|CS-W002229

Structure of 15726-38-2

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General Information

  • CAS No. 15726-38-2
  • Cat. No. CS-W002229
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃BrN₂O₂
  • Molecular Weight 190.98
  • Synonym(s) Propene, 3-chloro-2- (chloromethyl)-
  • SMILES Oc1ncnc(c1Br)O

Description

5-Bromo-4,6-dihydroxypyrimidine delivers a bifunctional pyrimidine scaffold with complementary hydroxyl groups and a bromine substituent. This configuration enables direct functionalization in nucleophilic substitution or cross-coupling reactions. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions, making it suitable for use in medicinal chemistry and materials synthesis workflows.

Application

5-Bromo-4,6-dihydroxypyrimidine serves as a versatile building block for nucleoside analogs and heterocyclic scaffolds, enabling efficient functionalization via cross-coupling and substitution reactions. The bromo group facilitates palladium-catalyzed coupling, while the adjacent diol functionality offers sites for selective protection or derivatization. Bench-stable and readily purified by recrystallization, it functions reliably in synthetic workflows targeting pharmaceutical intermediates and agrochemical precursors.

Synthesis

  • Route1

    References

    • Thang; Watson; Best; Fam; Keep Synthetic Communications, 1993 , vol. 23, # 17 p. 2363 - 2369

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.24
  • LogP   0.6503
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

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