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Structure of 157335-97-2
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5-Bromo-4,6-dimethylpyrimidine is a bench-stable, electron-deficient pyrimidine derivative featuring two methyl groups flanking the bromine at C5. This substitution pattern enables efficient coupling in cross-coupling reactions and facilitates incorporation into heterocyclic scaffolds for medicinal chemistry and materials science applications.
5-Bromo-4,6-dimethylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its bromine substituent facilitates reliable C–Br bond functionalization, while the methyl groups enhance solubility and contribute to favorable metabolic stability. The compound exhibits excellent bench stability and is compatible with standard reaction conditions, making it ideal for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: