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CS-W001157 4
Total: USD 88.00

2-Methoxy-4-(trifluoromethyl)aniline

  • CAS No. 158727-56-1

  • Cat. No. CS-0074358
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-4-(trifluoromethyl)aniline|CS-0074358

Structure of 158727-56-1

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General Information

  • CAS No. 158727-56-1
  • Cat. No. CS-0074358
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃NO
  • Molecular Weight 191.15
  • Synonym(s) None
  • SMILES FC(F)(F)C(C=C1OC)=CC=C1N

Description

2-Methoxy-4-(trifluoromethyl)aniline features a trifluoromethyl group that imparts strong electron-withdrawing character, while the methoxy substituent provides resonance donation. This electronic duality enhances its utility in constructing advanced intermediates for pharmaceuticals and agrochemicals. The compound exhibits robust stability under standard bench conditions and integrates readily into coupling reactions.

Application

2-Methoxy-4-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds. Its ortho-methoxy and para-trifluoromethyl groups provide enhanced metabolic stability and modulate electronic properties. The compound exhibits good bench stability, facilitates Suzuki-Miyaura coupling, and functions effectively in amide bond formation, supporting efficient access to complex heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.2962
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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