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Structure of 158727-56-1
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2-Methoxy-4-(trifluoromethyl)aniline features a trifluoromethyl group that imparts strong electron-withdrawing character, while the methoxy substituent provides resonance donation. This electronic duality enhances its utility in constructing advanced intermediates for pharmaceuticals and agrochemicals. The compound exhibits robust stability under standard bench conditions and integrates readily into coupling reactions.
2-Methoxy-4-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds. Its ortho-methoxy and para-trifluoromethyl groups provide enhanced metabolic stability and modulate electronic properties. The compound exhibits good bench stability, facilitates Suzuki-Miyaura coupling, and functions effectively in amide bond formation, supporting efficient access to complex heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: