Fmoc-Gly-NH-CH2-O-CH2COOH

Name: Fmoc-Gly-NH-CH2-O-CH2COOH
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CAS No. 1599440-08-0
Cat. No. CS-0064391
Molecule weight384.38
Purity≥95%
MDL No.MFCD32639967

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General Information

CAS No. 1599440-08-0
Cat. No. CS-0064391
Purity ≥95%
MDL No. MFCD32639967
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₂₀N₂O₆
Molecular Weight 384.38
Synonym(s) 1-(9H-Fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oic acid
SMILES O=C(O)COCNC(CNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)=O

Description

Fmoc-Gly-NH-CH2-O-CH2COOH is a specialized amino acid derivative designed for peptide synthesis and conjugation workflows. The Fmoc group enables efficient N-terminal protection, while the hydrophilic linker facilitates solubility and selective coupling. This compound integrates seamlessly into solid-phase protocols, offering reliable deprotection and minimal side reactions under standard conditions.

Application

Fmoc-Gly-NH-CH₂-O-CH₂COOH serves as a versatile bifunctional building block for peptide and peptidomimetic synthesis, enabling efficient conjugation via its terminal carboxylic acid and amine-functionalized linker. The Fmoc group provides orthogonal protection for the amino terminus, while the glycinyl spacer offers enhanced solubility and stability. Its robust compatibility with standard coupling reagents and ease of purification make it well-suited for solid-phase and solution-phase workflows in medicinal chemistry and macrocycle construction.

Safety Information

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Computational Chemistry Data

TPSA 113.96
LogP 1.7
H_Acceptors 5
H_Donors 3
Rotatable_Bonds 8

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Fmoc PEG

Life Science ADC Related Compound ADC Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Fmoc-Gly-NH-CH2-O-CH2COOH

CAS No. 1599440-08-0

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