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1-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one

  • CAS No. 16223-25-9

  • Cat. No. CS-0206931
  • Molecule weight216.28
  • Purity≥98%
  • MDL No.MFCD03426085

*For research and further manufacturing use only, not for direct human use.

1-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one|CS-0206931

Structure of 16223-25-9

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General Information

  • CAS No. 16223-25-9
  • Cat. No. CS-0206931
  • Purity ≥98%
  • MDL No. MFCD03426085
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₆N₂O
  • Molecular Weight 216.28
  • Synonym(s) 1-piperidin-4-yl-3H-indol-2-one
  • SMILES C1=CC=C2C(=C1)CC(=O)N2C3CCNCC3

Synthesis

  • Route1
    • null|null
      16223-24-8
    • ~76%
    • 1-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one|CS-0206931
      16223-25-9

    References

    • SRI INTERNATIONAL Patent: WO2005/60947 A2, 2005 ; Location in patent: Page/Page column 34 ; WO 2005/060947 A2
  • Route2
    • tert-butyl 4-(2-oxoindolin-1-yl)piperidine-1-carboxylate|CS-0515128
      400797-94-6
    • ~99%
    • 1-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one|CS-0206931
      16223-25-9

    References

    • Butler, Christopher R.; Cai, Hui; Edwards, James P.; Grice, Cheryl A.; Gu, Yin; Gustin, Darin J.; Karlsson, Lars; Khatuya, Haripada; Meduna, Steven P.; Pio, Barbara A.; Sehon, Clark A.; Sun, Siquan; Tays, Kevin L.; Thurmond, Robin L.; Wei, Jianmei Patent: US2005/101587 A9, 2005 ;
  • Route3

    References

    • van den Hoogenband, Adri; Lange, Jos H.M.; Iwema-Bakker, Wouter I.; den Hartog, Jack A.J.; van Schaik, Jord; Feenstra, Rolf W.; Terpstra, Jan Willem Tetrahedron Letters, 2006 , vol. 47, # 26 p. 4361 - 4364

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   32.34
  • LogP   1.3277
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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