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Structure of 162252-92-8
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6-(Trifluoromethoxy)-1H-indole-2,3-dione features a trifluoromethoxy group at the 6-position of the indole-2,3-dione scaffold, imparting enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables efficient incorporation into bioactive molecule synthesis, particularly in medicinal chemistry campaigns targeting kinase inhibition and protein-protein interactions. The compound exhibits good solubility in common organic solvents and maintains stability under standard bench conditions.
6-(Trifluoromethoxy)-1H-indole-2,3-dione serves as a versatile building block for heterocyclic synthesis, enabling efficient access to indole-based scaffolds through standard electrophilic and transition-metal-catalyzed transformations. Its trifluoromethoxy group enhances metabolic stability and modulates electronic properties, while the diketone core facilitates regioselective functionalization. The compound exhibits excellent bench stability and is compatible with common purification methods, making it well-suited for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: