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tert-Butyl N-({3-aminobicyclo[1.1.1]pentan-1-yl}methyl)carbamate

  • CAS No. 1630906-49-8

  • Cat. No. CS-0048094
  • Purity≥95%
  • MDL No.MFCD27987306

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-({3-aminobicyclo[1.1.1]pentan-1-yl}methyl)carbamate|CS-0048094

Structure of 1630906-49-8

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General Information

  • CAS No. 1630906-49-8
  • Cat. No. CS-0048094
  • Purity ≥95%
  • MDL No. MFCD27987306
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₀N₂O₂
  • Molecular Weight 212.29
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NCC12CC(N)(C1)C2

Description

tert-Butyl N-({3-aminobicyclo[1.1.1]pentan-1-yl}methyl)carbamate features a rigid bicyclo[1.1.1]pentane scaffold that imparts exceptional metabolic stability and conformational restraint. The pendant amine enables straightforward derivatization, while the tert-butyl carbamate group provides robust protection under standard conditions. This combination delivers a versatile, bench-stable building block for medicinal chemistry campaigns requiring enhanced physicochemical properties.

Application

tert-Butyl N-({3-aminobicyclo[1.1.1]pentan-1-yl}methyl)carbamate serves as a stable, bench-ready amine protecting group derivative featuring a rigid bicyclic core. Its tertiary amine functionality enables efficient incorporation into diverse synthetic sequences, particularly in the construction of constrained peptidomimetics and bioactive heterocycles. The carbamate moiety offers orthogonal deprotection compatibility and facilitates purification via standard chromatographic methods.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   1.3925
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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