tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate

Name: tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate
Brand: ChemScene
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CAS No. 1638763-38-8
Cat. No. CS-0042479
Purity≥97%
MDL No.MFCD21648497

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate|CS-0042479

Structure of 1638763-38-8

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General Information

CAS No. 1638763-38-8
Cat. No. CS-0042479
Purity ≥97%
MDL No. MFCD21648497
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂N₂O₂
Molecular Weight 226.32
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CC2(C1)CCC(N)C2

Description

tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate delivers a rigid, nitrogen-rich spirocyclic scaffold ideal for medicinal chemistry. This bench-stable derivative features a protected amine and a strategically positioned azaspiro framework that enhances conformational control in target engagement. The tert-butyl ester enables straightforward deprotection under mild acidic conditions, facilitating downstream functionalization.

Application

tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry, enabling efficient access to constrained nitrogen-containing heterocycles. The protected amine and carboxylate groups offer orthogonal functionalization potential, while the rigid spiro framework enhances conformational control in target molecules. Its bench-stable nature and compatibility with standard coupling and reduction protocols facilitate straightforward synthesis of complex scaffolds relevant to drug discovery.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 55.56
LogP 1.7347
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate

CAS No. 1638763-38-8

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