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CS-W001157 4
Total: USD 88.00

Di-tert-butyl 1-(trifluoromethyl)hydrazine-1,2-dicarboxylate

  • CAS No. 1644529-01-0

  • Cat. No. CS-0341530
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Di-tert-butyl 1-(trifluoromethyl)hydrazine-1,2-dicarboxylate|CS-0341530

Structure of 1644529-01-0

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Description

Di-tert-butyl 1-(trifluoromethyl)hydrazine-1,2-dicarboxylate features a trifluoromethyl-substituted hydrazine core flanked by tert-butyl ester groups, enabling stable incorporation of the CF₃ moiety into complex molecular architectures. This bench-stable reagent streamlines access to fluorinated heterocycles and functionalized intermediates in synthetic organic chemistry.

Application

Di-tert-butyl 1-(trifluoromethyl)hydrazine-1,2-dicarboxylate serves as a stable, bench-ready hydrazine equivalent for the selective introduction of trifluoromethyl groups into heterocyclic systems. It functions as a key building block in the synthesis of fluorinated nitrogen-containing scaffolds, enabling efficient C–N bond formation under mild conditions with excellent functional group tolerance. Its tert-butyl ester protection ensures high stability and ease of purification, making it well-suited for iterative synthetic strategies in medicinal chemistry and process development.

General Information

  • CAS No. 1644529-01-0
  • Cat. No. CS-0341530
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉F₃N₂O₄
  • Molecular Weight 300.27
  • Synonym(s) 1,2-Hydrazinedicarboxylic acid, 1-(trifluoromethyl)-, 1,2-bis(1,1-dimethylethyl) ester
  • SMILES N(NC(OC(C)(C)C)=O)(C(OC(C)(C)C)=O)C(F)(F)F

Computational Chemistry Data

  • TPSA   67.87
  • LogP   3.183
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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