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CS-W001157 4
Total: USD 88.00

5-Methyl-3-pyridinesulfonyl chloride

  • CAS No. 166337-57-1

  • Cat. No. CS-0023560
  • Purity≥97%
  • MDL No.MFCD13188992

*For research and further manufacturing use only, not for direct human use.

5-Methyl-3-pyridinesulfonyl chloride|CS-0023560

Structure of 166337-57-1

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General Information

  • CAS No. 166337-57-1
  • Cat. No. CS-0023560
  • Purity ≥97%
  • MDL No. MFCD13188992
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO₂S
  • Molecular Weight 191.64
  • Synonym(s) 5-Methyl-pyridine-3-sulfonyl chloride
  • SMILES O=S(C1=CC(C)=CN=C1)(Cl)=O

Description

5-Methyl-3-pyridinesulfonyl chloride features a pyridine ring with methyl and sulfonyl chloride groups positioned for selective electrophilic reactivity. This bench-stable derivative enables efficient coupling in amide bond formation, particularly useful in synthesizing bioactive sulfonamide conjugates and functionalized heterocycles under mild conditions.

Application

5-Methyl-3-pyridinesulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of a pyridylsulfonyl group into organic molecules. It facilitates amide and sulfonamide formation under mild conditions, exhibits good bench stability, and enables straightforward purification. Its functional group tolerance supports applications in medicinal chemistry and process development, particularly in constructing heterocyclic scaffolds and modulating physicochemical properties of API candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.03
  • LogP   1.31752
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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