4-Chloro-3-methylisoxazol-5-amine

Name: 4-Chloro-3-methylisoxazol-5-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 166964-09-6
Cat. No. CS-M0026
Molecule weight132.55
Purity≥98%
MDL No.MFCD08443950

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-methylisoxazol-5-amine|CS-M0026

Structure of 166964-09-6

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 166964-09-6
Cat. No. CS-M0026
Purity ≥98%
MDL No. MFCD08443950
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₅ClN₂O
Molecular Weight 132.55
Synonym(s) 5-Amino-4-chloro-3-methylisoxazole
SMILES ClC1=C(N)ON=C1C

Description

4-Chloro-3-methylisoxazol-5-amine features a reactive isoxazole core with complementary electron-withdrawing and donor substituents, enabling direct incorporation into diverse heterocyclic scaffolds. This bench-stable, moisture-tolerant building block facilitates efficient synthesis of bioactive compounds through coupling and cyclization reactions under standard conditions.

Application

4-Chloro-3-methylisoxazol-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to isoxazole-based pharmacophores. Its chloro and amino groups provide orthogonal handles for palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting heterocyclic drug candidates.

Synthesis

Route1
- In-stock
  
  14678-02-5
- ~90%
- In-stock
  
  166964-09-6
References
- Immunopharmaceutics, Inc. Patent: US5514691 A1, 1996 ;
Route2
- In-stock
  
  14678-02-5
- In-stock
  
  128-09-6
- ~42%
- In-stock
  
  166964-09-6
References
- Texas Biotechnology Corporation Patent: US6420567 B1, 2002 ; US 6420567 B1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 52.05
LogP 1.21862
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Isoxazole compounds

Key Words

4-Chloro-3-methylisoxazol-5-amine sigma4-Chloro-3-methylisoxazol-5-amine manufacturer4-Chloro-3-methylisoxazol-5-amine price4-Chloro-3-methylisoxazol-5-amine structure4-Chloro-3-methylisoxazol-5-amine SDSbuy 4-Chloro-3-methylisoxazol-5-amine4-Chloro-3-methylisoxazol-5-amine supplier4-Chloro-3-methylisoxazol-5-amine uses4-Chloro-3-methylisoxazol-5-amine molecular weightprice of 4-Chloro-3-methylisoxazol-5-amine4-Chloro-3-methylisoxazol-5-amine chemical name formula of 4-Chloro-3-methylisoxazol-5-amine

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-3-methylisoxazol-5-amine

CAS No. 166964-09-6

Recommended Products