3-Chloro-4-methoxypyridazine

Name: 3-Chloro-4-methoxypyridazine
Brand: ChemScene
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CAS No. 1677-81-2
Cat. No. CS-0700550
Molecule weight144.56
Purity≥97%
MDL No.MFCD28661715

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1677-81-2
Cat. No. CS-0700550
Purity ≥97%
MDL No. MFCD28661715
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂O
Molecular Weight 144.56
Synonym(s) None
SMILES COC1=CC=NN=C1Cl

Description

3-Chloro-4-methoxypyridazine is a heterocyclic building block featuring a chlorine substituent at the 3-position and a methoxy group at the 4-position, enabling selective functionalization in medicinal chemistry. This electron-deficient pyridazine core facilitates coupling reactions under mild conditions, offering high reactivity in cross-coupling and nucleophilic substitution processes. The molecule exhibits excellent stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, streamlining integration into multi-step synthetic sequences.

Application

3-Chloro-4-methoxypyridazine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–Cl bond. The methoxy group enhances solubility and modulates electronic properties, while the pyridazine core provides a stable, heteroaromatic scaffold for constructing bioactive molecules. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex intermediates.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 35.01
LogP 1.1386
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Ether

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

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3-Chloro-4-methoxypyridazine

CAS No. 1677-81-2

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