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Structure of 169674-57-1
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5-Chloro-6-fluoro-1H-indole is a fluorinated indole scaffold featuring orthogonal halogen substituents at the 5- and 6-positions, enabling selective functionalization in medicinal chemistry. This electron-deficient heterocycle integrates readily into bioactive molecules, offering enhanced metabolic stability and improved binding affinity in target-directed synthesis.
5-Chloro-6-fluoro-1H-indole serves as a valuable building block for the synthesis of fluorinated heterocyclic compounds, particularly in medicinal chemistry and agrochemical research. Its electron-deficient indole core enables regioselective functionalization at C2 and C3 positions, while the halogen substituents facilitate palladium-catalyzed cross-coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows requiring orthogonal reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: