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Structure of 1706450-11-4
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6-(Difluoromethyl)pyridazin-3-amine features a difluoromethyl group appended to a pyridazin-3-amine scaffold, delivering enhanced metabolic stability and favorable lipophilicity. This electron-deficient heterocycle integrates readily into medicinal chemistry programs targeting kinase inhibitors and CNS-penetrant therapeutics. The fluorinated side chain improves membrane permeability while maintaining solubility under standard conditions.
6-(Difluoromethyl)pyridazin-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the pyridazinamine core supports diverse transformations including Suzuki-Miyaura coupling, amide formation, and electrophilic substitution. Its bench-stable nature and compatibility with common protecting groups facilitate efficient synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P264-P270-P280-P330-P501
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Lot numbers can be found on the outside label of a product: