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CS-W001157 4
Total: USD 88.00

2-Aminopyrimidine-5-carbonitrile

  • CAS No. 1753-48-6

  • Cat. No. CS-W005758
  • Purity≥95%
  • MDL No.MFCD00232791
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Aminopyrimidine-5-carbonitrile|CS-W005758

Structure of 1753-48-6

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Description

2-Aminopyrimidine-5-carbonitrile features a dual functional group architecture with an amino group at the 2-position and a nitrile moiety at the 5-position, enabling versatile integration into heterocyclic scaffolds. This electron-deficient pyrimidine core facilitates coupling reactions under mild conditions, offering high reactivity in transition metal-catalyzed transformations. The compound demonstrates robust stability under standard bench protocols, supporting efficient incorporation into pharmaceutical intermediates and advanced materials.

Application

2-Aminopyrimidine-5-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of purine and pyrimidine-based scaffolds. Its dual functionality—amine and nitrile groups—supports diverse transformations including nucleophilic substitution, cyclization, and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development and heterocyclic library generation.

General Information

  • CAS No. 1753-48-6
  • Cat. No. CS-W005758
  • Purity ≥95%
  • MDL No. MFCD00232791
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₄
  • Molecular Weight 120.11
  • Synonym(s) 5-Pyrimidinecarbonitrile, 2-amino- (7CI,8CI,9CI)
  • SMILES N#CC1=CN=C(N)N=C1

Computational Chemistry Data

  • TPSA   75.59
  • LogP   -0.06952
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501

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