1,4-Dioxaspiro[4.5]decane

Name: 1,4-Dioxaspiro[4.5]decane
Brand: ChemScene
Availability: InStock
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CAS No. 177-10-6
Cat. No. CS-0155307
Purity≥98%
MDL No.MFCD00005409

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 177-10-6

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Description

1,4-Dioxaspiro[4.5]decane features a rigid spirocyclic framework with two oxygen atoms positioned at the 1- and 4-positions, delivering exceptional thermal stability and controlled solubility in polar aprotic solvents. This scaffold serves as a robust molecular anchor for medicinal chemistry campaigns requiring constrained conformational space and enhanced metabolic resistance.

Application

1,4-Dioxaspiro[4.5]decane serves as a robust, bench-stable spirocyclic scaffold enabling efficient construction of complex heterocyclic systems. Its rigid, oxygen-bridged structure provides excellent functional group tolerance and facilitates regioselective transformations in medicinal chemistry applications. The compound functions as a versatile building block for synthesizing bioactive molecules, particularly in the development of constrained analogs where conformational control enhances target affinity.

General Information

CAS No. 177-10-6
Cat. No. CS-0155307
Purity ≥98%
MDL No. MFCD00005409
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₄O₂
Molecular Weight 142.20
Synonym(s) None
SMILES C1CCC2(CC1)OCCO2

Computational Chemistry Data

TPSA 18.46
LogP 1.6936
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Spirol Rings compounds

Key Words

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1,4-Dioxaspiro[4.5]decane

CAS No. 177-10-6

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