tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate

Name: tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 177276-41-4
Cat. No. CS-0093983
Purity≥95%
MDL No.MFCD04973999

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate|CS-0093983

Structure of 177276-41-4

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Description

tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate serves as a pivotal building block in medicinal chemistry, featuring a sterically hindered tert-butyl ester and a piperazine-piperidine hybrid scaffold. This combination enables efficient incorporation into bioactive molecules, offering enhanced solubility and metabolic stability under standard conditions.

Application

tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to complex nitrogen-rich scaffolds. The piperazine moiety offers strong hydrogen-bonding capacity and metabolic stability, while the tert-butyl carbamate group provides excellent bench stability and orthogonal deprotection under mild acidic conditions. It functions as a key intermediate in the synthesis of GPCR-targeted compounds and kinase inhibitors, facilitating rapid diversification through standard amine coupling and reductive amination protocols.

General Information

CAS No. 177276-41-4
Cat. No. CS-0093983
Purity ≥95%
MDL No. MFCD04973999
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₇N₃O₂
Molecular Weight 269.39
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CCC(N2CCNCC2)CC1

Computational Chemistry Data

TPSA 44.81
LogP 1.2911
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate

CAS No. 177276-41-4

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