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Structure of 1779942-70-9
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8,8-Difluoro-3-azabicyclo[3.2.1]octane hydrochloride is a sterically constrained, electron-deficient heterocycle featuring two fluorine atoms at the bridgehead positions. This configuration imparts enhanced metabolic stability and modulates basicity, enabling its use as a key scaffold in medicinal chemistry for targeted CNS drug discovery.
8,8-Difluoro-3-azabicyclo[3.2.1]octane hydrochloride serves as a conformationally constrained, fluorinated nitrogen heterocycle ideal for medicinal chemistry applications. The difluoro substitution at the bridgehead positions enhances metabolic stability and modulates lipophilicity, while the tertiary amine functionality enables facile salt formation and solubility optimization. This scaffold functions effectively in ligand design, facilitating target engagement through defined spatial orientation and improved binding affinity in GPCR and kinase targets.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: