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Structure of 1780891-13-5
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4-(Difluoromethyl)pyrimidin-2-amine features a difluoromethyl group attached to a pyrimidine scaffold, delivering enhanced metabolic stability and improved membrane permeability. This electron-deficient heterocycle integrates readily into kinase inhibitor scaffolds and serves as a key building block in medicinal chemistry campaigns targeting ATP-binding sites.
4-(Difluoromethyl)pyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group into bioactive molecules. Its pyrimidine core facilitates hydrogen bonding and π-stacking interactions, while the amine functionality supports direct derivatization or incorporation into diverse heterocyclic scaffolds. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, making it well-suited for parallel synthesis campaigns and lead optimization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: