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CS-W001157 4
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tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate hydrochloride

  • CAS No. 178312-58-8

  • Cat. No. CS-0048251
  • Molecule weight277.79
  • Purity≥97%
  • MDL No.MFCD17169879

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate hydrochloride|CS-0048251

Structure of 178312-58-8

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General Information

  • CAS No. 178312-58-8
  • Cat. No. CS-0048251
  • Purity ≥97%
  • MDL No. MFCD17169879
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₄ClN₃O₂
  • Molecular Weight 277.79
  • Synonym(s) None
  • SMILES Cl.O=C(OC(C)(C)C)N1CCN(CC1)C2CNC2

Description

tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate hydrochloride features a rigid azetidine ring integrated into a piperazine scaffold, delivering enhanced metabolic stability and improved membrane permeability. This bench-stable derivative facilitates efficient incorporation into complex molecular architectures, particularly in kinase inhibitor and CNS-targeted compound development.

Application

tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate hydrochloride serves as a versatile building block for medicinal chemistry, enabling efficient access to azetidine-containing piperazine scaffolds. The protected piperazine moiety offers enhanced solubility and stability, while the azetidinyl group provides a conformationally constrained amine for targeted receptor interactions. Its hydrochloride salt form ensures improved handling and crystallinity, facilitating purification and consistent performance in standard coupling reactions and reductive amination protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   44.81
  • LogP   0.9327
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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