1-(Difluoromethyl)cyclopropan-1-amine hydrochloride

Name: 1-(Difluoromethyl)cyclopropan-1-amine hydrochloride
Brand: ChemScene
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CAS No. 1803595-15-4
Cat. No. CS-0063280
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(Difluoromethyl)cyclopropan-1-amine hydrochloride|CS-0063280

Structure of 1803595-15-4

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Description

This difluoromethylcyclopropane derivative features a sterically constrained cyclopropane ring bearing a difluoromethyl group and a primary amine, stabilized as its hydrochloride salt. The electron-withdrawing fluorine atoms enhance metabolic stability while preserving nucleophilic reactivity of the amine. This bench-stable crystalline solid integrates readily into medicinal chemistry libraries for probing bioisosteric effects in CNS-targeted compounds.

Application

1-(Difluoromethyl)cyclopropan-1-amine hydrochloride serves as a versatile building block for fluorinated bioactive molecules, enabling direct incorporation of the difluoromethyl group into medicinal chemistry scaffolds. The cyclopropane ring imparts conformational rigidity, while the amine functionality facilitates straightforward derivatization and salt formation. Its bench-stable hydrochloride form ensures ease of handling, purification, and compatibility with standard peptide coupling and reductive amination protocols in synthetic workflows.

General Information

CAS No. 1803595-15-4
Cat. No. CS-0063280
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₈ClF₂N
Molecular Weight 143.56
Synonym(s) None
SMILES NC1(C(F)F)CC1.[H]Cl

Computational Chemistry Data

TPSA 26.02
LogP 1.1646
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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1-(Difluoromethyl)cyclopropan-1-amine hydrochloride

CAS No. 1803595-15-4

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