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Structure of 1805304-78-2
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6-Chloro-2-(difluoromethyl)-3-fluoropyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This fluorinated pyridine scaffold integrates readily into bioactive molecules, offering improved membrane permeability and resistance to oxidative degradation under standard conditions.
6-Chloro-2-(difluoromethyl)-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated alkyl motifs into heterocyclic scaffolds. Its difluoromethyl group enhances metabolic stability and modulates lipophilicity, while the chloro and fluoro substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The compound exhibits good bench stability and facilitates efficient synthesis of complex fluorinated pyridines used in API development.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1325
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Class : 4.1
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Packing Group : Ⅲ
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Hazard Statements : H225-H315-H319
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362+P364-P370+P378-P501
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Lot numbers can be found on the outside label of a product: