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Structure of 1818294-46-0
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Mal-PEG8-acid is a maleimide-functionalized polyethylene glycol derivative featuring a C8 spacer and terminal carboxylic acid. This structure enables site-specific conjugation to thiol-containing biomolecules under physiological conditions, with the acid group facilitating further derivatization or immobilization. The PEG8 spacer provides enhanced solubility and reduced steric hindrance.
Mal-PEG8-acid is a versatile bifunctional linker that combines maleimide and carboxylic acid termini with an eight-ethylene glycol unit spacer. It facilitates site-specific conjugation via Michael addition to thiols, while the terminal carboxylic acid enables amide coupling under standard conditions. The PEG8 spacer enhances solubility and reduces aggregation, making it ideal for bioconjugation applications in antibody-drug conjugates and peptide-protein labeling.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P233-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: