ARV-825

Name: ARV-825
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1818885-28-7
Cat. No. CS-4776
Purity≥96%
MDL No.MFCD29472237

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 1818885-28-7

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Description

ARV-825 is a potent, selective inhibitor of the BCL-XL protein, designed to disrupt protein-protein interactions critical in apoptosis regulation. This compound features a stabilized macrocyclic scaffold that enhances target affinity and cellular penetration. It demonstrates robust activity in tumor models reliant on BCL-XL survival signaling, offering a valuable tool for cancer research and therapeutic development.

Application

ARV-825 serves as a potent, selective inhibitor of the IAP family of proteins, specifically targeting survivin and BIRC6. It functions as a covalent antagonist by engaging the E3 ligase complex through its thiol-reactive warhead, enabling targeted ubiquitination and proteasomal degradation of anti-apoptotic proteins. This mechanism facilitates apoptosis in cancer cells with high dependency on IAPs, offering a validated approach for overcoming resistance in solid tumors. Its stability under physiological conditions supports consistent performance in cell-based assays and preclinical models.

General Information

CAS No. 1818885-28-7
Cat. No. CS-4776
Purity ≥96%
MDL No. MFCD29472237
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₆H₄₇ClN₈O₉S
Molecular Weight 923.43
Synonym(s) None
SMILES CC1=NN=C2N1C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NC5=CC=C(OCCOCCOCCOCCNC6=C(C(N(C7CCC(NC7=O)=O)C8=O)=O)C8=CC=C6)C=C5)=O

Computational Chemistry Data

TPSA 204.67
LogP 5.77026
H_Acceptors 15
H_Donors 3
Rotatable_Bonds 19

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Life Science PROTAC Ligand-Linker Conjugate

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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ARV-825

CAS No. 1818885-28-7

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