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Structure of 1950634-92-0
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dBET6 is a potent, selective degrader of BRD4 that integrates into the ubiquitin-proteasome system via a thalidomide-based E3 ligase recruiter. This bifunctional molecule features a high-affinity bromodomain inhibitor moiety paired with a stable linker, enabling efficient target protein degradation under physiological conditions.
dBET6 serves as a potent, cell-permeable degrader of BRD4, enabling targeted protein degradation via the ubiquitin-proteasome system. It functions as a bifunctional molecule linking a BRD4-binding domain to an E3 ligase recruiter, facilitating selective ubiquitination and subsequent degradation of the target protein. Its design supports robust activity in cellular assays and provides a validated tool for probing BET protein function in epigenetic research.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: