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Structure of 182491-21-0
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This bench-stable, moisture-tolerant carboxylic acid features a tetrahydropyran core functionalized with a phenyl group at the 4-position, enabling direct integration into complex molecular architectures. The electron-rich heterocycle and pendant aryl moiety facilitate coupling reactions under standard conditions, delivering high yields in synthetic sequences requiring robust, well-defined building blocks.
4-Phenyltetrahydro-2H-pyran-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. Its pendant carboxylic acid group facilitates straightforward derivatization, while the tetrahydropyran ring provides conformational rigidity and metabolic stability. The phenyl substituent enhances π-stacking potential and contributes to favorable lipophilic interactions. This compound exhibits good bench stability and is compatible with standard coupling reactions, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: