(R)-1-(2-Fluorophenyl)ethan-1-amine

Name: (R)-1-(2-Fluorophenyl)ethan-1-amine
Brand: ChemScene
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CAS No. 185545-90-8
Cat. No. CS-0000328
Purity≥97%
MDL No.MFCD03092993

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-1-(2-Fluorophenyl)ethan-1-amine|CS-0000328

Structure of 185545-90-8

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Description

(R)-1-(2-Fluorophenyl)ethan-1-amine is a chiral amine featuring a fluorinated aromatic ring and a stereogenic center. This bench-stable, moisture-tolerant building block integrates readily into asymmetric synthesis workflows. The para-fluoro substitution enhances metabolic stability while preserving reactivity in transition metal-catalyzed couplings.

Application

(R)-1-(2-Fluorophenyl)ethan-1-amine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of enantiomerically pure pharmaceutical intermediates. Its fluorinated aryl group enhances metabolic stability and modulates electronic properties, while the primary amine facilitates straightforward derivatization via acylation, alkylation, or coupling reactions. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it well-suited for scalable synthesis and process development workflows.

General Information

CAS No. 185545-90-8
Cat. No. CS-0000328
Purity ≥97%
MDL No. MFCD03092993
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₀FN
Molecular Weight 139.17
Synonym(s) Benzenemethanamine,2-fluoro-a-methyl-, (aR)-
SMILES FC1=C(C=CC=C1)[C@@H](C)N

Computational Chemistry Data

TPSA 26.02
LogP 1.8454
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 2735
Class : 8	Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-(2-Fluorophenyl)ethan-1-amine

CAS No. 185545-90-8

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