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Structure of 18605-16-8
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6-Fluoro-2-methyl-3-nitropyridine features a trifunctional pyridine core with electron-withdrawing nitro and fluoro groups paired with a methyl substituent. This combination imparts enhanced reactivity in cross-coupling processes, enabling efficient integration into complex heterocyclic scaffolds under mild conditions. The molecule exhibits excellent bench stability and solubility in common organic solvents.
6-Fluoro-2-methyl-3-nitropyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated pyridine scaffolds prevalent in pharmaceuticals. Its reactivity profile supports direct nucleophilic substitution at the C6-fluorine site, facilitating coupling with diverse amines and heterocycles under mild conditions. The 3-nitro group offers additional functionalization potential via reduction and subsequent cyclization, while the 2-methyl substituent provides steric and electronic modulation. Bench-stable and compatible with standard purification methods, this compound facilitates rapid diversification in API lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: