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CS-W001157 4
Total: USD 88.00

6-Fluoro-2-methyl-3-nitropyridine

  • CAS No. 18605-16-8

  • Cat. No. CS-0007515
  • Purity≥98%
  • MDL No.MFCD03095071
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-2-methyl-3-nitropyridine|CS-0007515

Structure of 18605-16-8

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Description

6-Fluoro-2-methyl-3-nitropyridine features a trifunctional pyridine core with electron-withdrawing nitro and fluoro groups paired with a methyl substituent. This combination imparts enhanced reactivity in cross-coupling processes, enabling efficient integration into complex heterocyclic scaffolds under mild conditions. The molecule exhibits excellent bench stability and solubility in common organic solvents.

Application

6-Fluoro-2-methyl-3-nitropyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated pyridine scaffolds prevalent in pharmaceuticals. Its reactivity profile supports direct nucleophilic substitution at the C6-fluorine site, facilitating coupling with diverse amines and heterocycles under mild conditions. The 3-nitro group offers additional functionalization potential via reduction and subsequent cyclization, while the 2-methyl substituent provides steric and electronic modulation. Bench-stable and compatible with standard purification methods, this compound facilitates rapid diversification in API lead optimization campaigns.

General Information

  • CAS No. 18605-16-8
  • Cat. No. CS-0007515
  • Purity ≥98%
  • MDL No. MFCD03095071
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FN₂O₂
  • Molecular Weight 156.11
  • Synonym(s) 6-Fluoro-3-nitro-2-picoline; 6-Fluoro-2-methyl-3-nitropyridine
  • SMILES O=[N+](C1=CC=C(F)N=C1C)[O-]

Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.43732
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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