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CS-W001157 4
Total: USD 88.00

Bis(3-(trifluoromethyl)phenyl)methanone

  • CAS No. 1868-00-4

  • Cat. No. CS-0187326
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Bis(3-(trifluoromethyl)phenyl)methanone|CS-0187326

Structure of 1868-00-4

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General Information

  • CAS No. 1868-00-4
  • Cat. No. CS-0187326
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₈F₆O
  • Molecular Weight 318.21
  • Synonym(s) LABOTEST-BB LT00159871
  • SMILES C1=CC(=CC(=C1)C(F)(F)F)C(=O)C2=CC(=CC=C2)C(F)(F)F

Description

Bis(3-(trifluoromethyl)phenyl)methanone features two electron-deficient aryl rings flanking a ketone group, enabling robust participation in cross-coupling and electrophilic aromatic substitution reactions. The trifluoromethyl substituents enhance stability and modulate reactivity, making this compound valuable in synthetic organic chemistry and pharmaceutical intermediate development.

Application

Bis(3-(trifluoromethyl)phenyl)methanone serves as a robust diaryl ketone building block in synthetic organic chemistry, enabling efficient construction of complex aromatic scaffolds. Its trifluoromethyl substituents enhance metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The molecule exhibits good bench stability and facilitates electrophilic functionalization, nucleophilic addition, and transition-metal-catalyzed coupling reactions. Widely used in the synthesis of heterocyclic intermediates and API precursors, it functions reliably in standard laboratory workflows.

Synthesis

  • Route1

    References

    • US4788206 A1, ;
  • Route2
    • null|null
      79-37-8
    • null|null
      1179318-32-1
    • ~69%
    • In-stock
      Bis(3-(trifluoromethyl)phenyl)methanone|CS-0187326
      1868-00-4

    References

    • Rao, Maddali L. N.; Venkatesh, Varadhachari; Dasgupta, Priyabrata Tetrahedron Letters, 2010 , vol. 51, # 38 p. 4975 - 4980
  • Route3
    • null|null
      79-37-8
    • null|null
      121899-80-7
    • ~70%
    • In-stock
      Bis(3-(trifluoromethyl)phenyl)methanone|CS-0187326
      1868-00-4

    References

    • Rao, Maddali L. N.; Venkatesh, Varadhachari; Dasgupta, Priyabrata Tetrahedron Letters, 2010 , vol. 51, # 38 p. 4975 - 4980

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   4.9552
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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