Tert-butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate

Name: Tert-butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate
Brand: ChemScene
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CAS No. 188975-15-7
Cat. No. CS-0169630
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Tert-butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate|CS-0169630

Structure of 188975-15-7

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Description

Tert-butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate features a fluorinated aromatic ring paired with a piperidine scaffold, enabling integration into bioactive molecules requiring enhanced metabolic stability and membrane permeability. The tert-butyl ester group offers convenient protection for the carboxylic acid functionality during synthetic manipulations. This intermediate supports efficient access to kinase inhibitors and CNS-targeted pharmaceuticals through straightforward deprotection and functionalization.

Application

Tert-butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted piperidine scaffolds. The ortho-fluoro substituent enhances metabolic stability and modulates electronic properties, while the tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. This compound functions effectively in standard coupling reactions and supports the construction of complex heterocyclic systems relevant to kinase inhibitors and CNS-targeted therapeutics.

General Information

CAS No. 188975-15-7
Cat. No. CS-0169630
Purity ≥96%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₃FN₂O₂
Molecular Weight 294.36
Synonym(s) None
SMILES O=C(N1CCC(C2=CC=C(N)C=C2F)CC1)OC(C)(C)C

Computational Chemistry Data

TPSA 55.56
LogP 3.5224
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Tert-butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate

CAS No. 188975-15-7

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