Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Bromo-6-(trifluoromethyl)pyridine

  • CAS No. 189278-27-1

  • Cat. No. CS-W007843
  • Purity≥98%
  • MDL No.MFCD00153087

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-(trifluoromethyl)pyridine|CS-W007843

Structure of 189278-27-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 189278-27-1
  • Cat. No. CS-W007843
  • Purity ≥98%
  • MDL No. MFCD00153087
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₃N
  • Molecular Weight 225.99
  • Synonym(s) 2-Bromo-6-trifluoromethylpyridine
  • SMILES FC(C1=CC=CC(Br)=N1)(F)F

Description

2-Bromo-6-(trifluoromethyl)pyridine features a trifluoromethyl group at the pyridine ring's para position, enhancing electron deficiency and enabling efficient cross-coupling. This bench-stable reagent integrates readily into Suzuki-Miyaura and Negishi reactions, delivering high yields in C–C bond formation under standard conditions.

Application

2-Bromo-6-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity profile. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the bromine facilitates selective functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing heterocyclic scaffolds and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • Cottet, Fabrice; Schlosser, Manfred European Journal of Organic Chemistry, 2002 , # 2 p. 327 - 330

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8629
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Bromo-6-(trifluoromethyl)pyridine sigma2-Bromo-6-(trifluoromethyl)pyridine manufacturer2-Bromo-6-(trifluoromethyl)pyridine price2-Bromo-6-(trifluoromethyl)pyridine structure2-Bromo-6-(trifluoromethyl)pyridine SDSbuy 2-Bromo-6-(trifluoromethyl)pyridine2-Bromo-6-(trifluoromethyl)pyridine supplier2-Bromo-6-(trifluoromethyl)pyridine uses2-Bromo-6-(trifluoromethyl)pyridine molecular weightprice of 2-Bromo-6-(trifluoromethyl)pyridine2-Bromo-6-(trifluoromethyl)pyridine chemical name formula of 2-Bromo-6-(trifluoromethyl)pyridine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label